Lentigo melanoma associated with Leser–Trélat syndrome

LeserTrlat syndrome is characterized by the sudden appearance of a large amount elements seborrheic keratosis. The associated with development malignant tumors internal organs. reason for probably production cytokines cells organs (transforming growth factor alpha (TGF-), epidermal (EGF), etc.) endogenous mediators that affect proliferation keratinocytes and cause rapid Currently, question paraneoplastic nature multiple keratosis remains open. article presents observation an 82-year-old patient lentigo-melanoma, who developed within short time, discusses how in this case it possible to consider as process. This interesting atypical clinical picture association lentigo-melanoma.